Pentanal → 1-[2-Fluoro-4-(trifluoromethyl)phenyl]pentan-1-one

HRID 241371Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[F:12].[CH:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17]>>[F:12][C:3]1[CH:4]=[C:5]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:7][C:2]=1[C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17]

Participants

Reactant 2

HCID 8063Pentanal

HCID 1424144-Bromo-3-fluorobenzotrifluoride

Product 1

HCID 668830121-[2-Fluoro-4-(trifluoromethyl)phenyl]pentan-1-one

Procedure

The titled compound was prepared from 1-bromo-2-fluoro-4-(trifluoromethyl)benzene (200 mg, 0.823 mmol) and valeraldehyde (0.05 mL, 0.8 mmol) in a procedure similar to that of Example 9 (1) as a pale yellow oil (114 mg, yield 97%).

Sources & evidence

ORD record: ord-60915907a5d54c8e94139f16747a5d93
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08648208B2

Reaction notes

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