Methyl 3-(4-acetyl-2-methylphenyl)acrylate → Methyl 3-[4-[3-[3-butyl-6-(trifluoromethyl)benzothiophen-2-yl]propenoyl]-2-methylphenyl]acrylate
Reaction equation
[CH2:1]([C:5]1[C:9]2[CH:10]=[CH:11][C:12]([C:14]([F:17])([F:16])[F:15])=[CH:13][C:8]=2[S:7][C:6]=1[CH:18]=O)[CH2:2][CH2:3][CH3:4].[C:20]([C:23]1[CH:28]=[CH:27][C:26]([CH:29]=[CH:30][C:31]([O:33][CH3:34])=[O:32])=[C:25]([CH3:35])[CH:24]=1)(=[O:22])[CH3:21]>>[CH2:1]([C:5]1[C:9]2[CH:10]=[CH:11][C:12]([C:14]([F:16])([F:15])[F:17])=[CH:13][C:8]=2[S:7][C:6]=1[CH:18]=[CH:21][C:20]([C:23]1[CH:28]=[CH:27][C:26]([CH:29]=[CH:30][C:31]([O:33][CH3:34])=[O:32])=[C:25]([CH3:35])[CH:24]=1)=[O:22])[CH2:2][CH2:3][CH3:4]Participants
3
Procedure
The titled compound was prepared from the above-mentioned 3-butyl-6-(trifluoromethyl)benzothiophen-2-carboxaldehyde (88 mg, 0.31 mmol) and methyl 3-(4-acetyl-2-methylphenyl)acrylate (67 mg, 0.31 mmol) in a procedure similar to that of Example 7 (1) as a yellow crystal (77 mg, yield 51%).
Sources & evidence
- ORD record
- ord-568702312e5c4c0e9e1272622354b0ab
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08648208B2
Reaction notes
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