Potassium Carbonate → HCID 14076484, compound

HRID 2413754Notes

Reaction equation

HRID 2413754 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH2:15][CH2:14][CH2:13][N:11]3[CH:12]=2)=[CH:4][CH:3]=1.[Br:16]Br.[OH-].[Na+].C([O-])([O-])=O.[K+].[K+]>C(Cl)Cl>[Br:16][C:12]1[N:11]2[CH2:13][CH2:14][CH2:15][C:10]2=[N:9][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 24408BromineHCID 105696305H-Pyrrolo[1,2-a]imidazole, 2-(4-fluorophenyl)-6,7-dihydro-

Product 1

HCID 14076484HCID 14076484, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A stirred solution of 100 mg (0.50 mmole) of 2-(4-fluorophenyl)-6,7-dihydro-[5H]-pyrrolo[1,2-a]imidazole, prepared as described in Example I, was treated dropwise with a solution of 90 mg (0.56 mmole) of bromine in 0.5 ml of methylene chloride. After 45 minutes, the solution was made basic with 5% aqueous NaOH and dried organics over anhydrous K2CO3. The solvent was removed in vacuo, and the residue was recrystallized from carbon tetrachloride-hexane to give the desired Example V title product, mp 188°-189° C. dec.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue was recrystallized from carbon tetrachloride-hexane

Sources & evidence

ORD record
ord-f7aff1602588445da02c266e084da3fd
Source dataset
uspto-grants-1988_01
Patent number
US04719218

Reaction notes

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