O-Methylhydroxylamine hydrochloride → HCID 86652869, compound

HRID 241378Notes

Reaction equation

HRID 241378 reaction equation
[CH:1]([C:4]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:15])[F:14])=[CH:12][C:7]=2[S:6][C:5]=1[CH2:17][CH2:18][C:19]([C:21]1[CH:33]=[CH:32][C:24]([O:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:23]([CH3:34])[CH:22]=1)=O)([CH3:3])[CH3:2].Cl.[CH3:36][O:37][NH2:38]>>[CH:1]([C:4]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:15])[F:14])=[CH:12][C:7]=2[S:6][C:5]=1[CH2:17][CH2:18][C:19]([C:21]1[CH:33]=[CH:32][C:24]([O:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:23]([CH3:34])[CH:22]=1)=[N:38][O:37][CH3:36])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 66883183HCID 66883183, compound

Product 1

HCID 86652869HCID 86652869, compound

Procedure

The titled compound was prepared from ethyl 4-[3-[3-isopropyl-6-(trifluoromethyl)benzothiophen-2-yl]propionyl]-2-methylphenoxyacetate [Example 15 (2)] (70 mg, 0.14 mmol) and methoxyamine hydrochloride (13 mg, 0.16 mmol) in a procedure similar to that of Example 13 (1) as a yellow oil (74 mg, yield>99%).

Sources & evidence

ORD record
ord-fe8729eb6f254250aa80640ed235cba3
Source dataset
uspto-grants-2014_02
Patent number
US08648208B2

Reaction notes

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