Hydrochloric Acid → HCID 20155241, compound

HRID 2413812Notes

Reaction equation

HRID 2413812 reaction equation
[Br-].C1(=O)[N:6]([CH2:7][CH2:8][N+:9]2[CH:14]=[CH:13][CH:12]=[C:11]([S:15]C(=O)C3C=CC=CC=3)[CH:10]=2)C(=O)C2=CC=CC=C12.[ClH:30]>>[ClH:30].[Cl-:30].[NH2:6][CH2:7][CH2:8][N+:9]1[CH:14]=[CH:13][CH:12]=[C:11]([SH:15])[CH:10]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 20155230HCID 20155230, compound

Product 1

HCID 20155241HCID 20155241, compound

Procedure

A suspension of 1-(2-phthalimidoethyl)-3-benzoylthiopyridinium bromide (40 g) in 6N hydrochloric acid (510 ml) was heated under reflux for 10 hours and cooled to room temperature. The resulting precipitates were filtered off and washed with water. The filtrate and the washings were combined and washed with chloroform. The separated aqueous layer was evaporated to dryness under reduced pressure. The residue was triturated in acetone, and the resulting precipites were collected by filtlation and dried in vacuo to give 1-(2-aminoethyl)-3-mercaptopyridinium chloride hydrochloride (18.1 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 10 hours
  3. customThe resulting precipitates
  4. filtrationwere filtered off
  5. washwashed with water
  6. washwashed with chloroform
  7. customThe separated aqueous layer was evaporated to dryness under reduced pressure
  8. customThe residue was triturated in acetone
  9. customthe resulting precipites were collected by filtlation
  10. customdried in vacuo

Sources & evidence

ORD record
ord-d58eeb71ec2a4a468b025267e2deb629
Source dataset
uspto-grants-1988_01
Patent number
US04719206

Reaction notes

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