反应详情

One equivalent difluoroethylacetate and one equivalent dodecylamine stirred at room temperature in acetonitrile 16 hours. The solvent is removed to give a white wax, which is chromatographed on silica gel in CHCl3 /EtOAc (15:1), Rf =0.7. NMR (CDCl3, δ) 7.2 b-s (1H); 5.9 g (2H) J=26; 3.35 m (2H); 1.3 s (20H); 0.9 m (3H). Other compounds prepared this way, with similar NMR, acceptable Mass Spectra and TLC: N-propyl-difluoroacetamide.

1. customThe solvent is removed
2. customto give a white wax, which
3. customis chromatographed on silica gel in CHCl3 /EtOAc (15:1), Rf =0.7
4. custom1.3 s (20H)
5. customOther compounds prepared this way