Hydrochloric Acid → HCID 70417261, compound

Participants

Reaction Steps

To an ice-cold solution of 3.7 g 1-tert.butyldimethylsilyl-2-oxo-3-(trans)-(1-hydroxy-1-methylethyl)azetidine-4-yl-acetic acid benzylester in 130 ml of methanol/water (9/1) are added 6.6 ml of conc. HCl. This mixture is stirred for 30 minutes at 0° and 31/2 hours at 25°. The solution is concentrated and the residue taken up in ethylacetate, washed once with aq. NaCl, dried over MgSO4 and evaporated to dryness to yield the title compound

Provenance & Evidence