Hydrochloric Acid → HCID 70417261, compound

HRID 2413886Notes

Reaction equation

HRID 2413886 reaction equation
[CH2:1]([O:8][C:9](=[O:27])[CH:10]([SiH](C)C)[C@@H:11]1[N:14](C(C)(C)C)[C:13](=[O:19])[C@H:12]1[C:20]([OH:23])([CH3:22])[CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>CO.O>[CH2:1]([O:8][C:9](=[O:27])[CH2:10][CH:11]1[NH:14][C:13](=[O:19])[CH:12]1[C:20]([OH:23])([CH3:21])[CH3:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131715437HCID 131715437, compound

Product 1

HCID 70417261HCID 70417261, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

To an ice-cold solution of 3.7 g 1-tert.butyldimethylsilyl-2-oxo-3-(trans)-(1-hydroxy-1-methylethyl)azetidine-4-yl-acetic acid benzylester in 130 ml of methanol/water (9/1) are added 6.6 ml of conc. HCl. This mixture is stirred for 30 minutes at 0° and 31/2 hours at 25°. The solution is concentrated and the residue taken up in ethylacetate, washed once with aq. NaCl, dried over MgSO4 and evaporated to dryness to yield the title compound

Workup

  1. custom2 hours
  2. customat 25°
  3. concentrationThe solution is concentrated
  4. washwashed once with aq. NaCl
  5. dry with materialdried over MgSO4
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-323315c1dad74ba1841f1a35ef80eff0
Source dataset
uspto-grants-1988_01
Patent number
US04720490

Reaction notes

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