Bromine → HCID 20154317, compound

HRID 2413899Notes

Reaction equation

HRID 2413899 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[S:8][C:9]([CH2:12][NH:13][C:14](=[O:16])[CH3:15])=[CH:10][CH:11]=2)[N:6]=1.[Br:17]Br>C(O)(=O)C>[BrH:17].[NH2:1][C:2]1[S:3][C:4]([Br:17])=[C:5]([C:7]2[S:8][C:9]([CH2:12][NH:13][C:14](=[O:16])[CH3:15])=[CH:10][CH:11]=2)[N:6]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 2560398N-[[5-(2-AMINO-1,3-THIAZOL-4-YL)THIEN-2-YL]METHYL]ACETAMIDE

Product 1

HCID 20154317HCID 20154317, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To a solution of 2.0 g of 2-amino-4-(5-acetylaminomethyl-2-thienyl]thiazole in 50 ml of acetic acid is added dropwise a solution of 1.44 g of bromine in 10 ml of acetic acid with stirring at room temperature for 15 minutes. After the whole mixture is stirred for an hour, the precipitated crystals are collected by filtration and washed with ether to give 2-amino-4-(5-acetylaminomethyl-2-thienyl)-5-bromothiazole hydrobromide, melting at 185° C.-186° C. with decomposition.

Workup

  1. stirringAfter the whole mixture is stirred for an hour
  2. filtrationthe precipitated crystals are collected by filtration
  3. washwashed with ether

Sources & evidence

ORD record
ord-beffad8a367f449e8b749fb9d27e109f
Source dataset
uspto-grants-1988_01
Patent number
US04720493

Reaction notes

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