HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → HCID 20154317, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | N-{[5-(2-amino-1,3-thiazol-4-yl)thiophen-2-yl]methyl}acetamide | HCID 2560398 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 20154317 | HCID 20154317 | — |
Reaction Steps
To a solution of 2.0 g of 2-amino-4-(5-acetylaminomethyl-2-thienyl]thiazole in 50 ml of acetic acid is added dropwise a solution of 1.44 g of bromine in 10 ml of acetic acid with stirring at room temperature for 15 minutes. After the whole mixture is stirred for an hour, the precipitated crystals are collected by filtration and washed with ether to give 2-amino-4-(5-acetylaminomethyl-2-thienyl)-5-bromothiazole hydrobromide, melting at 185° C.-186° C. with decomposition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04720493 |
| Source dataset | uspto-grants-1988_01 |
| ORD ID | ord-beffad8a367f449e8b749fb9d27e109f |
| Source note | uspto-grants-1988_01 |