反应详情

温度

140 °C

A mixture consisting of 2-amino-7-chloro-1,8-naphthyridine (1.8 g), 4-chlorophenol (12.85 g) and 85% strength potassium hydroxide pellets (1.1 g) is heated for 8 hours at 140° C. The reaction mixture is poured into distilled water (200 cc) and made alkaline to a pH of 10 with 4N sodium hydroxide. The suspension obtained is filtered and washed with distilled water to a pH of approximately 7. The solid obtained is air-dried to give 2-amino-7-(4-chlorophenoxy)-1,8-naphthyridine (2 g), m.p. 177° C.

1. additionThe reaction mixture is poured
2. distillationinto distilled water (200 cc)
3. customThe suspension obtained
4. filtrationis filtered
5. washwashed with distilled water to a pH of approximately 7
6. customThe solid obtained
7. customis air-dried