Ethyl formate → HCID 13983424, compound

Participants

Reaction Steps

The procedure is analogous to that described in Example 11, but starting with sodium (2.3 g), 3,4-dichloroacetophenone (19 g) and ethyl formate (11 g). The solid then obtained (22.7 g) is added to 2,6-diaminopyridine (11.6 g). The product obtained after hydrolysis and neutralization with 10N sodium hydroxide (22.4 g; m.p. approximately 140° C.) is dissolved in concentrated hydrochloric acid (d=1.19; 200 cc). The precipitate obtained after hydrolysis with distilled water (300 cc) followed by neutralization with 10N sodium hydroxide, is separated by filtration, washed with distilled water (5×50 cc) and air-dried. 2-Amino-7-(3,4-dichlorophenyl)-1,8-naphthyridine (14.6 g), m.p. 210° C., is obtained.

Provenance & Evidence