反应详情

1.5 g of 1A was mixed with 25 ml of distilled water and a few boiling chips and boiled under a nitrogen blanket. After 40 minutes reflux, the initial oily two phase system became homogenous. The water was stripped on a rotary evaporator and the product readily crystallized. After drying in a vacuum oven at 60°, N-benzylazetidine-3-carboxylic acid (1), m.p.: 152°-154°, was obtained.

1. temperatureAfter 40 minutes reflux
2. customThe water was stripped on a rotary evaporator
3. customthe product readily crystallized
4. customAfter drying in a vacuum oven at 60°