Methyl 1-benzylazetidine-3-carboxylate → 1-Benzylazetidine-3-carboxylic acid

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Reaction Steps

1.5 g of 1A was mixed with 25 ml of distilled water and a few boiling chips and boiled under a nitrogen blanket. After 40 minutes reflux, the initial oily two phase system became homogenous. The water was stripped on a rotary evaporator and the product readily crystallized. After drying in a vacuum oven at 60°, N-benzylazetidine-3-carboxylic acid (1), m.p.: 152°-154°, was obtained.

Provenance & Evidence