反应详情

To a stirred mixture of 5-bromothiophene-2-sulfonamide (24.2 g, 0.10 mol) in acetonitrile (100 ml) was added dimethylformamide dimethyl acetal (14 ml) in acetonitrile (125 ml) dropwise over 0.5 hour. After an additional 0.5 hour the solvent was removed in vacuo. The residue was treated with water and the solid that precipitated was collected and dried, 28.7 g., m.p. 103°-105° C. Recrystallization from 1-chlorobutane gave material with m.p. 104°-106° C.

1. customAfter an additional 0.5 hour the solvent was removed in vacuo
2. additionThe residue was treated with water
3. customthe solid that precipitated
4. customwas collected
5. customdried
6. customRecrystallization from 1-chlorobutane
7. customgave material with m.p. 104°-106° C.