HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → Benzyl-[4-(4-methylpiperazine-1-sulfonyl)-2-nitrophenyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | 1-[(4-Chloro-3-nitrophenyl)sulfonyl]-4-methylpiperazine | HCID 2842419 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | Benzyl-[4-(4-methylpiperazine-1-sulfonyl)-2-nitrophenyl]amine | HCID 9186770 | — |
Reaction Steps
17.2 2.8 g (8.756 mmol) of 1-(4-chloro-3-nitrobenzenesulfonyl)-4-methylpiperazine are dissolved in 10 ml of 1-butanol, and 1.913 ml (17.5 mmol) of benzylamine are added. The reaction mixture is heated under reflux for 14 h. After cooling, MTBE is added, the precipitate formed is filtered off with suction and washed with MTBE and dried in vacuo, giving benzyl-[4-(4-methylpiperazine-1-sulfonyl)-2-nitrophenyl]amine; HPLC-MS [M+H]+ 391.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648201B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-0af41d8e01274460a393a3f59cb0fb95 |
| Source note | uspto-grants-2014_02 |