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HRID241418

反应详情

EQUATION

反应方程式

HRID 241418 的结构方程式

REACTANTS

反应物

3
结构：NCc1ccccc1
HCID7504

Benzylamine

C7H9N

结构：COC(C)(C)C
HCID15413

Methyl tert-butyl ether

C5H12O

结构：CN1CCN(S(=O)(=O)c2ccc(Cl)c([N+](=O)[O-])c2)CC1
HCID2842419

1-[(4-chloro-3-nitrophenyl)sulfonyl]-4-methylpiperazine

C11H14ClN3O4S

PRODUCTS

生成物

1
结构：CN1CCN(S(=O)(=O)c2ccc(NCc3ccccc3)c([N+](=O)[O-])c2)CC1
HCID9186770

T5929645

C18H22N4O4S

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCO
溶剂HCID263

1-Butanol

C4H10O

PROCEDURE

实验过程

17.2 2.8 g (8.756 mmol) of 1-(4-chloro-3-nitrobenzenesulfonyl)-4-methylpiperazine are dissolved in 10 ml of 1-butanol, and 1.913 ml (17.5 mmol) of benzylamine are added. The reaction mixture is heated under reflux for 14 h. After cooling, MTBE is added, the precipitate formed is filtered off with suction and washed with MTBE and dried in vacuo, giving benzyl-[4-(4-methylpiperazine-1-sulfonyl)-2-nitrophenyl]amine; HPLC-MS [M+H]+ 391.2.

WORKUP

后处理

  1. temperatureThe reaction mixture is heated
  2. temperatureunder reflux for 14 h
  3. temperatureAfter cooling
  4. customthe precipitate formed
  5. filtrationis filtered off with suction
  6. washwashed with MTBE
  7. customdried in vacuo