反应详情

4-methylsulfonamidobenzenesulfonyl chloride (2.70 g) was added portionwise to a 0.01 mole portion of N-isopropylethylenediamine and triethylamine (0.01 mole) in methylene chloride (250 ml) to obtain a white solid which precipitated from the methylene chloride reaction mixture 2.62 g, m.r. 180°-182° C. This solid was washed well with methylene chloride, dissolved in isopropanol/HCl/methanol and the methanol boiled away. The product was precipitated and filtered to yield 1.65 g, m.r. 158°-160° C.(d).

1. customto obtain a white solid which
2. customprecipitated from the methylene chloride reaction mixture 2.62 g, m.r
3. custom180°-182° C
4. washThis solid was washed well with methylene chloride
5. dissolutiondissolved in isopropanol/HCl/methanol
6. customThe product was precipitated
7. filtrationfiltered
8. customto yield 1.65 g, m.r