Formamide, N-[2-[3-(methylthio)phenyl]ethyl]- → 3,4-Dihydro-6-(methylthio)isoquinoline

HRID 2414250Notes

Reaction equation

HRID 2414250 reaction equation
COC1C=C(CCNC=O)C=CC=1.[CH3:14][S:15][C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][NH:24][CH:25]=O)[CH:19]=[CH:20][CH:21]=1>>[CH3:14][S:15][C:16]1[CH:17]=[C:18]2[C:19](=[CH:20][CH:21]=1)[CH:25]=[N:24][CH2:23][CH2:22]2

Participants

3

Reactant 2

HCID 10976389Formamide, N-[2-[3-(methylthio)phenyl]ethyl]-HCID 13562936N-[2-(3-Methoxyphenyl)ethyl]formamide

Product 1

HCID 110194053,4-Dihydro-6-(methylthio)isoquinolineYield 13.3%

Procedure

A procedure identical to that described for the preparation of N-[2-(3-methoxy-phenyl)-ethyl]-formamide in Example 1 was followed using N-[2-(3-methylsulfanyl-phenyl)-ethyl]-formamide (6.7 g, 34 mmol) to give the desired product (0.8 g, 13%). MS: 178.1 (M+1+).

Sources & evidence

ORD record
ord-a0d458abc5884a77a9867c0b8aad4925
Source dataset
uspto-grants-2004_11
Patent number
US06812228B2

Reaction notes

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