反应详情

40.4 g of methyl 4-chloro-3-methylbenzoate, 39 g of N-bromosuccinimide and 1 g of azobisisobutyronitrile were added to 300 ml of carbon tetrachloride, followed by reflux under heating for 4 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, insoluble matters were collected by filtration and the filtrate was concentrated. The obtained crude crystals were washed with hexane to obtain 34.3 g of methyl 3-bromomethyl-4-chlorobenzoate as white crystals.

1. temperatureby reflux
2. temperatureunder heating for 4 hours
3. customAfter completion of the reaction
4. filtrationinsoluble matters were collected by filtration
5. concentrationthe filtrate was concentrated
6. customThe obtained crude crystals
7. washwere washed with hexane