反应详情

A solution of the product from example 1 (0.9 g) and carbonyldiimidazole (1.1 equiv.) in dichloromethane (4 ml) was stirred at room temperature for 1 h, poured onto aqueous ammonia and stirred for a further 1 h. The mixture was extracted with ethyl acetate, the organics washed with water, dried and evaporated under reduced pressure. Purification was by chromatography eluting with 2.5% methanol/dichloromethane. Yield 0.01 g as a solid.

1. extractionThe mixture was extracted with ethyl acetate
2. washthe organics washed with water
3. customdried
4. customevaporated under reduced pressure
5. customPurification
6. washeluting with 2.5% methanol/dichloromethane