6-chloro-N-isopropylnicotinamide → n-(1-Methylethyl)-6-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide

HRID 2414313Notes

Reaction equation

HRID 2414313 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:10][CH:11]([CH3:13])[CH3:12])=[O:9])=[CH:4][CH:3]=1.Cl.[NH:15]1[CH2:20][CH2:19][CH:18]([N:21]2[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[CH2:24][O:23][C:22]2=[O:31])[CH2:17][CH2:16]1>>[CH3:12][CH:11]([NH:10][C:8]([C:5]1[CH:6]=[N:7][C:2]([N:15]2[CH2:16][CH2:17][CH:18]([N:21]3[C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=4[CH2:24][O:23][C:22]3=[O:31])[CH2:19][CH2:20]2)=[CH:3][CH:4]=1)=[O:9])[CH3:13]

Participants

3

Reactant 2

HCID 8193696-chloro-N-isopropylnicotinamideHCID 220630891-(4-Piperidinyl)-1,2-dihydro-4H-3,1-benzoxazin-2-one hydrochloride

Product 1

HCID 22644661n-(1-Methylethyl)-6-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide

Procedure

The title compound was prepared from the product of step (i) (0.4 g) and 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride (0.5 g) using the method of example 115 step (ii). Yield 0.22 g.

Sources & evidence

ORD record
ord-8b104c0f09c94428a312fe631fd09ad5
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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