HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-chloro-N-isopropylnicotinamide → n-(1-Methylethyl)-6-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-chloro-N-isopropylnicotinamide | HCID 819369 | — |
| Reactant | 1-(4-Piperidinyl)-1,2-dihydro-4H-3,1-benzoxazin-2-one hydrochloride | HCID 22063089 | — |
| Product | n-(1-Methylethyl)-6-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide | HCID 22644661 | — |
Reaction Steps
The title compound was prepared from the product of step (i) (0.4 g) and 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride (0.5 g) using the method of example 115 step (ii). Yield 0.22 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06812226B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-8b104c0f09c94428a312fe631fd09ad5 |
| Source note | uspto-grants-2004_11 |