1-(4-Piperidinyl)-1,2-dihydro-4H-3,1-benzoxazin-2-one hydrochloride → 3-Pyridinecarboxamide, 5-chloro-N-(1-methylethyl)-6-[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)-1-piperidinyl]-

HRID 2414315Notes

Reaction equation

HRID 2414315 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([NH:11][CH:12]([CH3:14])[CH3:13])=[O:10])[CH:5]=[N:6][C:7]=1Cl.Cl.[NH:16]1[CH2:21][CH2:20][CH:19]([N:22]2[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=3[CH2:25][O:24][C:23]2=[O:32])[CH2:18][CH2:17]1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([NH:11][CH:12]([CH3:14])[CH3:13])=[O:10])[CH:5]=[N:6][C:7]=1[N:16]1[CH2:17][CH2:18][CH:19]([N:22]2[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=3[CH2:25][O:24][C:23]2=[O:32])[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 220630891-(4-Piperidinyl)-1,2-dihydro-4H-3,1-benzoxazin-2-one hydrochlorideHCID 226446015,6-Dichloro-N-isopropylnicotinamide

Product 1

HCID 226445683-Pyridinecarboxamide, 5-chloro-N-(1-methylethyl)-6-[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)-1-piperidinyl]-

Procedure

The title compound was prepared from the product of step (i) (0.3 g) and 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride (0.35 g) using the method of example 115 step (ii). Yield 0.187 g.

Sources & evidence

ORD record
ord-bfbc3115fdf3474c9601d1bee78f7455
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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