反应详情

Iron powder (1.5 g) was added to a solution of the product from step (i) (1.37 g) in acetic acid (50 ml) and tetrahydrofuran (20 ml). After stirring at room temperature for 5 h, the mixture was filtered through celite, the solvent removed under reduced pressure and the residue partitioned between ethyl acetate and aqueous sodium hydrogencarbonate solution. The organic layer was washed with water, dried and evaporated under reduced pressure. Purification was by chromatography eluting with 50% ethyl acetate/isohexane. Yield 1.05 g.

1. filtrationthe mixture was filtered through celite
2. customthe solvent removed under reduced pressure
3. customthe residue partitioned between ethyl acetate and aqueous sodium hydrogencarbonate solution
4. washThe organic layer was washed with water
5. customdried
6. customevaporated under reduced pressure
7. customPurification
8. washeluting with 50% ethyl acetate/isohexane