Isopropylamine → HCID 22644644, compound

HRID 2414322Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[C:11]#[N:12].C(N1C=CN=C1)(N1C=CN=C1)=O.[CH:25]([NH2:28])([CH3:27])[CH3:26]>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:28][CH:25]([CH3:27])[CH3:26])=[O:8])=[CH:4][C:3]=1[C:11]#[N:12]

Participants

Reactant 3

HCID 6363Isopropylamine

HCID 682631,1'-Carbonyldiimidazole

HCID 226446124-Chloro-3-cyanobenzoic acid

Product 1

HCID 22644644HCID 22644644, compound

Procedure

The above compound was prepared from the product of step (ii) (0.6 g), carbonyldiimidazole (0.59 g) and isopropylamine (0.51 ml) using the method of example 115 step (i). Yield 0.68 g.

Sources & evidence

ORD record: ord-b8cead684b6b4a8c8ad7fd2cf83fdb54
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06812226B2

Reaction notes

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