HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(4-Piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(1-Boc-4-piperidyl)-4-methyl-3,1-benzoxazin-2-one | HCID 22914730 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(4-Piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride | HCID 22644681 | — |
Reaction Steps
4M Hydrogen chloride in 1,4-dioxane (20 ml) was added to a solution of the product from step (i) (1.4 g) in 1,4-dioxane (20 ml) and the mixture stirred at room temperature overnight. The solvent was removed under reduced pressure and the residue triturated with ether. Yield 1.0 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06812226B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-0d6a6ce1d9c343c29cba647af95ca2b8 |
| Source note | uspto-grants-2004_11 |