Hydrochloric Acid → 1-(4-Piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride

HRID 2414329Notes

Reaction equation

HRID 2414329 reaction equation
[ClH:1].[CH3:2][CH:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[C:5](=[O:26])[O:4]1>O1CCOCC1>[ClH:1].[CH3:2][CH:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[C:5](=[O:26])[O:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 229147301-(1-Boc-4-piperidyl)-4-methyl-3,1-benzoxazin-2-one

Product 1

HCID 226446811-(4-Piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

4M Hydrogen chloride in 1,4-dioxane (20 ml) was added to a solution of the product from step (i) (1.4 g) in 1,4-dioxane (20 ml) and the mixture stirred at room temperature overnight. The solvent was removed under reduced pressure and the residue triturated with ether. Yield 1.0 g.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe residue triturated with ether

Sources & evidence

ORD record
ord-0d6a6ce1d9c343c29cba647af95ca2b8
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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