6-chloro-N-isopropylnicotinamide → 5-Chloro-n-(1-methylethyl)-6-[4-(4-methyl-2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide

HRID 2414330Notes

Reaction equation

HRID 2414330 reaction equation
[ClH:1].[CH3:2][CH:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[C:5](=[O:19])[O:4]1.Cl[C:21]1[N:26]=[CH:25][C:24]([C:27]([NH:29][CH:30]([CH3:32])[CH3:31])=[O:28])=[CH:23][CH:22]=1>>[Cl:1][C:22]1[CH:23]=[C:24]([C:27]([NH:29][CH:30]([CH3:32])[CH3:31])=[O:28])[CH:25]=[N:26][C:21]=1[N:16]1[CH2:17][CH2:18][CH:13]([N:6]2[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[CH:3]([CH3:2])[O:4][C:5]2=[O:19])[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 8193696-chloro-N-isopropylnicotinamideHCID 226446811-(4-Piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride

Product 1

HCID 226446375-Chloro-n-(1-methylethyl)-6-[4-(4-methyl-2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide

Procedure

The title compound was prepared from the product of step (ii) (0.36 g) and the product from example 117 step (i) (0.466 g) using the method of example 115 step (ii). Yield 0.112 g

Sources & evidence

ORD record
ord-372703aa2407456fb403edf33930f71c
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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