5,6-Dichloronicotinic acid → 5-Chloro-6-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxylic acid

HRID 2414335Notes

Reaction equation

HRID 2414335 reaction equation
[Cl:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].Cl.[NH:13]1[CH2:18][CH2:17][CH:16]([N:19]2[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[CH2:22][O:21][C:20]2=[O:29])[CH2:15][CH2:14]1>>[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[CH:5]=[N:4][C:3]=1[N:13]1[CH2:14][CH2:15][CH:16]([N:19]2[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[CH2:22][O:21][C:20]2=[O:29])[CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 2479875,6-Dichloronicotinic acidHCID 220630891-(4-Piperidinyl)-1,2-dihydro-4H-3,1-benzoxazin-2-one hydrochloride

Product 1

HCID 226445845-Chloro-6-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxylic acid

Procedure

The title compound was prepared from 5,6-dichloronicotinic acid (2.2 g) and 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride (3.0 g) using the method of example 115 step (ii). Yield 0.037 g

Sources & evidence

ORD record
ord-b64a875cfeaa4a06b8a48623da903126
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

Loading…