HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6-Dichloronicotinic acid → 5-Chloro-6-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6-Dichloronicotinic acid | HCID 247987 | — |
| Reactant | 1-(4-Piperidinyl)-1,2-dihydro-4H-3,1-benzoxazin-2-one hydrochloride | HCID 22063089 | — |
| Product | 5-Chloro-6-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxylic acid | HCID 22644584 | — |
Reaction Steps
The title compound was prepared from 5,6-dichloronicotinic acid (2.2 g) and 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride (3.0 g) using the method of example 115 step (ii). Yield 0.037 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06812226B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-b64a875cfeaa4a06b8a48623da903126 |
| Source note | uspto-grants-2004_11 |