1,1'-Carbonyldiimidazole → HCID 22644623, compound

HRID 2414338Notes

Reaction equation

HRID 2414338 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:25](O)=[O:26])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH2:17][O:16][C:15]2=[O:24])[CH2:10][CH2:9]1.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH3:40][C:41]([NH2:45])([C:43]#[CH:44])[CH3:42]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:25]([NH:45][C:41]([CH3:42])([CH3:40])[C:43]#[CH:44])=[O:26])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH2:17][O:16][C:15]2=[O:24])[CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 763193-Butyn-2-amine, 2-methyl-HCID 226445845-Chloro-6-[4-(2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxylic acid

Product 1

HCID 22644623HCID 22644623, compound

Procedure

The title compound was prepared from the product of example 148 step (i) (0.14 g), carbonyldiimidazole (0.064 g) and 1,1-dimethylpropargylamine (0.06 g) using the method of example 115 step (i). Purification was by chromatography eluting with ethyl acetate/isohexane (2/3). Yield 0.03 g as a solid.

Workup

  1. customPurification
  2. washeluting with ethyl acetate/isohexane (2/3)

Sources & evidence

ORD record
ord-bda2125e71e9497a9aa3405af5dda0c6
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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