6-chloro-N-isopropylnicotinamide → 5-Chloro-n-(1-methylethyl)-6-[4-(3-oxo-2,3-dihydro-4h-1,4-benzoxazin-4-yl)piperidin-1-yl]pyridine-3-carboxamide

HRID 2414342Notes

Reaction equation

HRID 2414342 reaction equation
[ClH:1].[NH:2]1[CH2:7][CH2:6][CH:5]([N:8]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][CH2:10][C:9]2=[O:18])[CH2:4][CH2:3]1.Cl[C:20]1[N:25]=[CH:24][C:23]([C:26]([NH:28][CH:29]([CH3:31])[CH3:30])=[O:27])=[CH:22][CH:21]=1>>[Cl:1][C:21]1[CH:22]=[C:23]([C:26]([NH:28][CH:29]([CH3:31])[CH3:30])=[O:27])[CH:24]=[N:25][C:20]=1[N:2]1[CH2:3][CH2:4][CH:5]([N:8]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][CH2:10][C:9]2=[O:18])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 8193696-chloro-N-isopropylnicotinamideHCID 226445984-Piperidin-4-yl-4h-benzo[1,4]oxazin-3-one hydrochloride

Product 1

HCID 226445925-Chloro-n-(1-methylethyl)-6-[4-(3-oxo-2,3-dihydro-4h-1,4-benzoxazin-4-yl)piperidin-1-yl]pyridine-3-carboxamide

Procedure

The title compound was prepared from 4-piperidin-4-yl-4H-benzo[1,4]oxazin-3-one hydrochloride (WO 9502405) (0.13 g) and the product from example 117 step (i) (0.13 g) according to the method of example 115 step (ii). Yield 0.04 g as a solid.

Sources & evidence

ORD record
ord-5ed5bfd262584790994b37f9ff879995
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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