HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-chloro-N-isopropylnicotinamide → 5-Chloro-n-(1-methylethyl)-6-[4-(3-oxo-2,3-dihydro-4h-1,4-benzoxazin-4-yl)piperidin-1-yl]pyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-chloro-N-isopropylnicotinamide | HCID 819369 | — |
| Reactant | 4-Piperidin-4-yl-4h-benzo[1,4]oxazin-3-one hydrochloride | HCID 22644598 | — |
| Product | 5-Chloro-n-(1-methylethyl)-6-[4-(3-oxo-2,3-dihydro-4h-1,4-benzoxazin-4-yl)piperidin-1-yl]pyridine-3-carboxamide | HCID 22644592 | — |
Reaction Steps
The title compound was prepared from 4-piperidin-4-yl-4H-benzo[1,4]oxazin-3-one hydrochloride (WO 9502405) (0.13 g) and the product from example 117 step (i) (0.13 g) according to the method of example 115 step (ii). Yield 0.04 g as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06812226B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-5ed5bfd262584790994b37f9ff879995 |
| Source note | uspto-grants-2004_11 |