Water → HCID 12132661, compound

HRID 2414354Notes

Reaction equation

HRID 2414354 reaction equation
C([O:4][CH2:5][C:6]1[C:32]([F:33])=[C:31]([NH2:34])[C:9]2[C:10](=[O:30])[CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:28])[CH2:22][CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])=[C:16]([F:29])[CH:15]=3)[O:13][C:8]=2[C:7]=1[F:35])(=O)C.[OH-].[Na+].O>CO>[NH2:34][C:31]1[C:9]2[C:10](=[O:30])[CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:28])[CH2:22][CH2:23][CH2:24][N:25]([CH3:26])[CH3:27])=[C:16]([F:29])[CH:15]=3)[O:13][C:8]=2[C:7]([F:35])=[C:6]([CH2:5][OH:4])[C:32]=1[F:33]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 12132659HCID 12132659, compound

Product 1

HCID 12132661HCID 12132661, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 1j (363 mg, 0.739 mmol) in methanol (36 mL) was added 1 mol/L sodium hydroxide (4 mL), and the mixture was stirred at room temperature for 20 minutes. Water was added thereto and the crystals precipitated were collected by filtration. Purification by silica gel column chromatography gave a free base of 1k (299 mg, 69%), which was converted into a hydrochloride.

Workup

  1. customthe crystals precipitated
  2. filtrationwere collected by filtration
  3. customPurification by silica gel column chromatography

Sources & evidence

ORD record
ord-c3ca9120d3774776a54b514c08cdb244
Source dataset
uspto-grants-2004_11
Patent number
US06812246B2

Reaction notes

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