HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 12132661, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 12132659 | HCID 12132659 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 12132661 | HCID 12132661 | 90% |
Reaction Steps
To a suspension of 1j (363 mg, 0.739 mmol) in methanol (36 mL) was added 1 mol/L sodium hydroxide (4 mL), and the mixture was stirred at room temperature for 20 minutes. Water was added thereto and the crystals precipitated were collected by filtration. Purification by silica gel column chromatography gave a free base of 1k (299 mg, 69%), which was converted into a hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06812246B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-c3ca9120d3774776a54b514c08cdb244 |
| Source note | uspto-grants-2004_11 |