Ethanol → Ethyl 4-methyl-2-(pyridin-4-yl)-1,3-thiazole-5-carboxylate

HRID 2414416Notes

Reaction equation

HRID 2414416 reaction equation
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[C:10]([O:13][CH2:14][CH3:15])(=[O:12])[CH3:11].[CH2:16](O)[CH3:17]>>[CH3:16][C:17]1[N:9]=[C:1]([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=2)[S:8][C:11]=1[C:10]([O:13][CH2:14][CH3:15])=[O:12]

Participants

4

Reactant 3

HCID 702EthanolHCID 8857Ethyl AcetateHCID 27237884-Pyridinecarbothioamide

Product 1

HCID 619089Ethyl 4-methyl-2-(pyridin-4-yl)-1,3-thiazole-5-carboxylate

Procedure

2.76 g (20 mmol) of thioisonicotinamide and 3.6 g (22 mmol) of ethyl 2-chloroacetacetate were heated under reflux in 30 ml of ethanol for 20 hours. After the treatment with ethyl acetate as the extraction solvent in an ordinary manner, the obtained crude product was purified by the silica gel column chromatography to obtain the title compound.

Workup

  1. customwas purified by the silica gel column chromatography

Sources & evidence

ORD record
ord-e34d6d10997b4f978758c026530c9f18
Source dataset
uspto-grants-2004_11
Patent number
US06812231B2

Reaction notes

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