Methylamine → HCID 10163458, compound

HRID 2414539Notes

Reaction equation

HRID 2414539 reaction equation
N1(C2C=C[C:10]([NH:13][C:14]([C:16]3[NH:17][C:18]4[C:23](C(=O)C=3)=CC(OC)=CC=4Br)=O)=CC=2)CCOCC1.CN.[N:32]1([C:38]2[CH:43]=[CH:42][C:41]([NH:44][C:45]([C:47]3[CH:56]=[C:55]([NH:57][CH3:58])[C:54]4[C:49](=[C:50](Br)[CH:51]=[C:52]([O:59][CH3:60])[CH:53]=4)[N:48]=3)=[O:46])=[CH:40][CH:39]=2)[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[N:32]1([C:38]2[CH:43]=[CH:42][C:41]([NH:44][C:45]([C:47]3[CH:56]=[C:55]([NH:57][CH3:58])[C:54]4[C:49](=[C:50]([N:17]5[CH2:16][CH2:14][N:13]([CH3:10])[CH2:23][CH2:18]5)[CH:51]=[C:52]([O:59][CH3:60])[CH:53]=4)[N:48]=3)=[O:46])=[CH:40][CH:39]=2)[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 86587185HCID 86587185, compoundHCID 86587189HCID 86587189, compound

Product 1

HCID 10163458HCID 10163458, compound

Procedure

The title compound was prepared from 8-bromo-6-methoxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid (Reference Example 27b) according to the procedure described for Example 98 using N-methyl amine to prepare 8-bromo-4-methylamino-6-methoxy-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide. A glassy orange solid was obtained. Mass Spec.: calc. for [C27H34N6O3+H]+ Theor. m/z=491; Obs.=491.5.

Workup

  1. customA glassy orange solid was obtained

Sources & evidence

ORD record
ord-9c07b1898a824b879107f33cd5071669
Source dataset
uspto-grants-2004_11
Patent number
US06812225B2

Reaction notes

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