反应详情

温度

60 °C

Dissolve N-[5-[6-(difluoromethyl)-3-pyridyl]-4-methyl-1H-imidazol-2-yl]acetamide (0.172 g, 0.65 mmol) in MeOH (5 mL) and water (5 mL). Heat the mixture to 60° C. Add hydrochloric acid (12 N, 5 mL, 60 mmol). Stir mixture for 2 hours at 60° C. Concentrate the mixture to a volume of about 10 mL. Adjust the pH of the aqueous solution to 8. Extract the resulting solution with EtOAc (2×20 mL). Dry the combined organic extracts over sodium sulfate; filter; collect the filtrate; and concentrate the filtrate under reduced pressure to give the title compound as a yellow oil (0.153 g, 100% crude yield). LCMS (m/z) 225 (M+1).

1. concentrationConcentrate the mixture to a volume of about 10 mL
2. extractionExtract the resulting solution with EtOAc (2×20 mL)
3. dry with materialDry the combined organic extracts over sodium sulfate
4. filtrationfilter
5. customcollect the filtrate
6. concentrationand concentrate the filtrate under reduced pressure