Dichloromethane → HCID 69802348, compound

HRID 2414614Notes

Reaction equation

HRID 2414614 reaction equation
[CH3:1][O:2][C:3](=[O:27])[CH:4]([NH:19]C(OC(C)(C)C)=O)[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:7][CH:6]=1.[Cl:28]CCl>>[ClH:28].[ClH:28].[NH2:19][CH:4]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH2:17][CH2:18]2)=[CH:7][CH:6]=1)[C:3]([O:2][CH3:1])=[O:27]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 86587125HCID 86587125, compound

Product 1

HCID 69802348HCID 69802348, compoundYield 100%

Procedure

To a solution of methyl[(tert-butoxycarbonyl)amino]{4-[2-(1-pyrrolidinyl)-ethoxy]phenyl}acetate was dissolved in dichloromethane, hydrogen chloride gas was bubbled in for 5 minutes. The reaction was then stirred at room temperature for 0.5 h. The solvent was removed to provide 1.80 g of methyl amino{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}acetate dihydrochloride as a light pink solid Yield ˜100%. mp 80° C. (d). Electrospray Mass Spec 279.2 (M+H)+.

Workup

  1. customhydrogen chloride gas was bubbled in for 5 minutes
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-6bdd19b4b13149ac9e0a453e8e814c73
Source dataset
uspto-grants-2004_11
Patent number
US06812227B2

Reaction notes

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