Hydrochloric Acid → HCID 21304715, compound

HRID 2414665Notes

Reaction equation

HRID 2414665 reaction equation
[CH3:1][C:2]1([CH3:28])[S:7][CH2:6][CH2:5][N:4]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]#[CH:20])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[C@H:3]1[C:21]([O:23]C(C)(C)C)=[O:22].Cl>ClCCl>[CH3:1][C:2]1([CH3:28])[S:7][CH2:6][CH2:5][N:4]([S:8]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:18][C:19]#[CH:20])=[CH:15][CH:16]=2)(=[O:9])=[O:10])[C@H:3]1[C:21]([OH:23])=[O:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21304724HCID 21304724, compound

Product 1

HCID 21304715HCID 21304715, compoundYield 93.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Through a solution of 0.271 g (0.638 mmol) of tert-butyl (3S)-2,2-dimethyl-4-{[4-(2-propynyloxy)phenyl]sulfonyl}-3-thiomorpholinecarboxylate in 10 mL of dichloromethane was bubbled hydrogen chloride gas for 10 minutes. The reaction was then stoppered and let sit overnight at room temperature. The solvent was evaporated to give 0.221 g of (3S)-2,2-dimethyl-4-{[4-(2-propynyloxy)phenyl]sulfonyl}-3-thiomorpholine carboxylic acid as a white solid. Electrospray Mass Spec 368.2 (M−H)−

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-d85af40f754740698db011ea72e751b8
Source dataset
uspto-grants-2004_11
Patent number
US06812227B2

Reaction notes

Loading…