3-Chloro-5-ethoxypyridine → 3-(5-Ethoxy-3-pyridyl)-3,7-diazabicyclo[3.3.0]octane

HRID 2414717Notes

Reaction equation

HRID 2414717 reaction equation
Cl[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH2:9][CH3:10])[CH:7]=1.[CH:11]12[CH2:18][NH:17][CH2:16][CH:15]1[CH2:14][NH:13][CH2:12]2.CC(C)([O-])C.[K+]>COCCOC>[CH2:9]([O:8][C:6]1[CH:7]=[C:2]([N:13]2[CH2:14][CH:15]3[CH:11]([CH2:18][NH:17][CH2:16]3)[CH2:12]2)[CH:3]=[N:4][CH:5]=1)[CH3:10]

Participants

5

Reactant 3

HCID 115211283-Chloro-5-ethoxypyridineHCID 21867666Octahydropyrrolo(3,4-c)pyrroleHCID 23665647Potassium tert-butoxide

Product 1

HCID 98780023-(5-Ethoxy-3-pyridyl)-3,7-diazabicyclo[3.3.0]octane

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

Obtainable by stirring a mixture of 3-chloro-5-ethoxypyridine (1 eq.), 3.7-Diazabicyclo[3.3.0]octane (1 eq.), potassium-tert-butoxide (2 eq.) and 1.2-dimethoxyethane as solvent. Workup-procedure A/B.

Sources & evidence

ORD record
ord-2dda6bea92294f008dfb36b26676ca27
Source dataset
uspto-grants-2004_11
Patent number
US06815438B2

Reaction notes

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