反应详情

温度

40 °C

1-Iodo-4-pentylbenzene (82 g, 0.3 mol), potassium carbonate (100 g, 0.72 mol), 2,3-difluorophenyl boronic acid (47 g, 0.3 mol), water (100 ml) and acetone (300 ml) were placed in a round-bottom three necked flask equipped with condenser, thermometer, mechanical stirrer, nitrogen inlet and outlet. The reaction flask was flushed with nitrogen and minor flow was held during whole reaction time. The mixture was heated up to the boiling point to degas the reaction system and then cooled down to 40° C. and the catalyst palladium acetate (0.1 g) was added. The temperature has increased by a few degrees and the solution turned brown. The mixture was refluxed for three days, then it was cooled down, poured on cold water and extracted with dichlorometane and the organic phase separated, dried over MgSO4 and dichlorometane was distilled off. The residue was distilled under reduced pressure at 0.2 mmHg collecting the fraction at 133° C. The colorless liquid fraction 41.5 g of was obtained, 53% of theor. yield.

1. customequipped with condenser
2. customThe reaction flask was flushed with nitrogen and minor flow
3. temperatureThe mixture was heated up to the boiling point
4. customto degas the reaction system
5. additionthe catalyst palladium acetate (0.1 g) was added
6. temperatureThe temperature has increased by a few degrees
7. temperatureThe mixture was refluxed for three days
8. temperatureit was cooled down
9. additionpoured on cold water
10. extractionextracted with dichlorometane
11. customthe organic phase separated
12. dry with materialdried over MgSO4 and dichlorometane
13. distillationwas distilled off
14. distillationThe residue was distilled under reduced pressure at 0.2 mmHg
15. customcollecting the fraction at 133° C
16. customThe colorless liquid fraction 41.5 g of was obtained
17. customyield