Hydrochloric Acid → HCID 22643446, compound

HRID 2414774Notes

Reaction equation

HRID 2414774 reaction equation
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([O:19][CH:20]4[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>CO>[ClH:32].[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([O:19][CH:20]4[CH2:24][CH2:23][NH:22][CH2:21]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11316672HCID 11316672, compound

Product 1

HCID 22643446HCID 22643446, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of thus-obtained t-butyl 3-{[1-(phenylsulfonyl)-1H-indol-4-yl]oxy}-1-pyrrolidinecarboxylate (0.41 g, 0.93 mmol) in methanol and HCl (5.0 ml, 1M in ether) is heated at 60° C. under nitrogen for 2 h and concentrated in vacuo. The residue is treated with ethyl acetate and filtered. The filtercake is dried under vacuum to give the title product as an off white solid, 0.301 g, mp 200-201° C., identified by NMR and mass spectral analyses.

Workup

  1. concentrationconcentrated in vacuo
  2. additionThe residue is treated with ethyl acetate
  3. filtrationfiltered
  4. customThe filtercake is dried under vacuum

Sources & evidence

ORD record
ord-b31ef5bab56044478cf4a32bab9eec1a
Source dataset
uspto-grants-2004_11
Patent number
US06815456B2

Reaction notes

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