Morpholine → HCID 22643409, compound

HRID 2414780Notes

Reaction equation

HRID 2414780 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[S:10][CH:11]([CH3:19])[CH2:12][CH2:13][C:14]([O:16]CC)=O.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[N:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[NH:1][C:2]=1[S:10][CH:11]([CH3:19])[CH2:12][CH2:13][C:14]([N:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1)=[O:16]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 22643414HCID 22643414, compound

Product 1

HCID 22643409HCID 22643409, compoundYield 57.6%

Procedure

0.56 g of ethyl 4-(2-benzimidazolylthio)valerate and 0.53 g of morpholine were heated at 100° C. for 20 hours. The reaction mixture was applied without treatment to a silica gel column for purification (methanol:methylene chloride=1:10), and 0.37 g of the title compound was obtained as solid (yield: 58%).

Workup

  1. customThe reaction mixture was applied without treatment to a silica gel column for purification (methanol:methylene chloride=1:10)

Sources & evidence

ORD record
ord-dd7fd86d26374cfda598d7f403a59eef
Source dataset
uspto-grants-2004_11
Patent number
US06815455B1

Reaction notes

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