Water → 1-(4-Bromovaleroyl)-4-methylpiperidine

HRID 2414781Notes

Reaction equation

HRID 2414781 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][CH:9]([CH3:15])[CH2:10][CH2:11][C:12](Cl)=[O:13].O>C(#N)C>[Br:8][CH:9]([CH3:15])[CH2:10][CH2:11][C:12]([N:5]1[CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3][CH2:4]1)=[O:13]

Participants

5

Reactant 3

HCID 962WaterHCID 693814-MethylpiperidineHCID 22643413HCID 22643413, compound

Product 1

HCID 226434181-(4-Bromovaleroyl)-4-methylpiperidineYield 82%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1.09 g of 4-methylpiperidine was dissolved in 10 ml of acetonitrile and added dropwise with 1.09 g of 4-bromovaleroyl chloride. The reaction mixture was stirred for 2 hours, then poured into water and extracted with ethyl acetate. The organic layer was washed with wafer and dried over sodium sulfate, and then the solvent was evaporated under reduced pressure to obtain 1.07 g of the title compound (yield: 82%).

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with wafer
  3. dry with materialdried over sodium sulfate
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-be3d31fd80a34a63842c8ba79f41da24
Source dataset
uspto-grants-2004_11
Patent number
US06815455B1

Reaction notes

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