3-(2,3-Difluorophenyl)-2-propenoic acid → 3-(2,3-difluorophenyl)propanoic Acid

HRID 2414818Notes

Reaction equation

HRID 2414818 reaction equation
[F:1][C:2]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].[H][H]>C(O)C.[Pd]>[F:1][C:2]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][C:6]([OH:8])=[O:7]

Participants

5

Reactant 2

HCID 27369613-(2,3-Difluorophenyl)-2-propenoic acidHCID 178418361HCID 178418361, compound

Product 1

HCID 37993363-(2,3-difluorophenyl)propanoic Acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a suspension of 2,3-difluoro-cinnamic acid (2.94 g, 16 mmol) in ethanol (100 mL) is added Pd (10% on carbon, 50 mg) and the mixture is treated with hydrogen (7.5 bar) for 15 h. The suspension is filtered through celite and the solvent evaporated to provide the title compound.

Workup

  1. filtrationThe suspension is filtered through celite
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-c809bc499ab64bc1afa716d459617a42
Source dataset
uspto-grants-2004_11
Patent number
US06815451B2

Reaction notes

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