反应详情

温度

80 °C

(8R)-2-Methyl-7,8-dihydro[1,4]dioxino[2,3-g][1,3]benzoxazol-8-ylmethyl 4-methylbenzenesulfonate (0.38 g, 1 mmole) and piperidine 15 ml were combined and heated at 80° C. under nitrogen for 4 hours. After completion, piperidine was removed under vacuum and the residue was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The organic phase was washed with brine, dried over magnesium sulfate and concentrated in vacuum. The crude oil was column chromatographed on silica gel using first methylene chloride to remove impurities and then 1% methanol/methylene chloride to elute the (S)-enantiomer of the title compound. This was recrystallized from ethanol with the addition of one equivalent of fumaric acid to give 0.24 g of white solid, m.p. 109-112° C.

1. customAfter completion, piperidine was removed under vacuum
2. customthe residue was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate
3. washThe organic phase was washed with brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated in vacuum
6. customchromatographed on silica gel using first methylene chloride
7. customto remove impurities
8. wash1% methanol/methylene chloride to elute the (S)-enantiomer of the title compound