Dimethylcarbamoyl Chloride → HCID 14173535, compound

HRID 2414853Notes

Reaction equation

[C:1]([NH:4][NH:5][C:6](=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:3])C.[N:14](C(Cl)=O)([CH3:16])[CH3:15]>>[C:6]([NH:5][NH:4][C:1](=[O:3])[N:14]([CH3:16])[CH3:15])(=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

Reactant 2

HCID 6598Dimethylcarbamoyl Chloride

HCID 256983Benzoic acid, 2-acetylhydrazide

Product 1

HCID 14173535HCID 14173535, compound

Procedure

Synthesis and isolation were same as 1-acetyl-2-benzoylhydrazine, using 1.5 g (11.2 mmol) of benzoylhydrazide, 1.2 g (11.2 mmol) of (CH3)2NCOCl and 1.11 g of TEA. Yield was 0.9 g (39%). 1H NMR (200 MHz, d6-DMSO) δ 2.90 (s, 6H), 7.50 (m, 3H), 7.90 (d, 3H), 8.45 (s, 1H), 10.05 (s, 1H); MS (EI, m/e, relative intensity %) calcd for C10H13N3O2 207, found 207 (M, 13.2); mp 199-201° C.

Workup

customSynthesis and isolation

Sources & evidence

ORD record: ord-8956bd32ee8b4ef2a67ee06091aa411a
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06815528B2

Reaction notes

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