Dimethylcarbamoyl Chloride → HCID 14173539, compound

HRID 2414857Notes

Reaction equation

C(NNC(=O)C1C=CC=CC=1)(=O)C.[CH3:14][O:15][C:16]1[CH:25]=[CH:24][C:19]([C:20]([NH:22][NH2:23])=[O:21])=[CH:18][CH:17]=1.[N:26]([C:29](Cl)=[O:30])([CH3:28])[CH3:27]>>[CH3:27][N:26]([CH3:28])[C:29]([NH:23][NH:22][C:20](=[O:21])[C:19]1[CH:18]=[CH:17][C:16]([O:15][CH3:14])=[CH:25][CH:24]=1)=[O:30]

Participants

Reactant 3

HCID 6598Dimethylcarbamoyl Chloride

HCID 767924-Methoxybenzohydrazide

HCID 256983Benzoic acid, 2-acetylhydrazide

Product 1

HCID 14173539HCID 14173539, compound

Procedure

Synthesis and isolation were same as for 1-acetyl-2-benzoylhydrazine, using 1.8 g (10.8 mmol) of 4-methoxybenzoylhydrazine, 1.2 g (11.1 mmol) of (CH3)2NCOCl, and 1.1 g of TEA. Yield was 1.5 g (59%). MS (EI, m/e) calcd for C11H15N3O3 237, found 237 (M+, 8.3); mp 218-220° C.

Workup

customSynthesis and isolation

Sources & evidence

ORD record: ord-f68bdcffbf9d4497a06af42a0cf350fc
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06815528B2

Reaction notes

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